Serious adverse reactions, including excessive weakness, dysphagia, and aspiration pneumonia, with some adverse reactions associated with fatal outcomes, have been reported in patients who received BOTOX injections for unapproved uses. In these cases, the adverse reactions were not necessarily related to distant spread of toxin, but may have resulted from the administration of BOTOX to the sitio of injection and/or adjacent structures.

Safety and effectiveness of BOTOX have not been established for the treatment of axillary hyperhidrosis in pediatric patients under age 18.

Repeat injections for hyperhidrosis should be administered when the clinical effect of a previous injection diminishes.

Getting "too much" Botox often means exceeding the amount needed for this subtle result, leading to undesirable cosmetic outcomes or potentially increasing side effect risks. It is important to be treated by a qualified, experienced medical professional (like a board-certified dermatologist, plastic surgeon, or properly trained nurse practitioner/physician assistant under supervision) who understands anatomy and appropriate dosing.

Muscle Strength and Mass: Individuals with stronger or larger facial muscles (often, but not always, correlating with male patients) will typically need more units to achieve the desired relaxation compared to those with weaker or smaller muscles.

Botox Cosmetic and Botox come as separate products but are both prescription medicines that contain the active ingredient onabotulinumtoxinA. Continue reading

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Overactive Bladder BOTOX for injection is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency, in adults who have an inadequate response to or are intolerant of an anticholinergic medication.

Reduced blinking from BOTOX injection of the orbicularis muscle can lead to corneal exposure, persistent epithelial defect, and corneal ulceration, especially in patients with VII nerve disorders.

Botox is not approved for the prevention of of episodic migraine (14 headache days or fewer per month), and also should not be used to treat a common tension headache.

Previous Botox History: If you've had Botox before, your injector will consider how you responded to previous treatments. Did the standard dose work well? Did it wear off quickly? Did you need a touch-up? This history helps refine the dosage for subsequent sessions.

Reconstituted BOTOX should be clear, colorless, and radiesse free of particulate matter. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration and whenever the solution and the container permit.

The potency Units of BOTOX are specific to the preparation and assay method utilized. They are not interchangeable with other preparations of botulinum toxin products and, therefore, units of biological activity of BOTOX cannot be compared to nor converted into units of any other botulinum toxin products assessed with any other specific assay method [see Description (11)]. 5.3 Serious Adverse Reactions with Unapproved Use

Vigorous blinking from Botox injection of the orbicularis muscle can lead to an epithelial defect and corneal ulceration. Consider protective drops, ointment, soft contact lenses, closure of the eye by patching or other means.